Glymphatic system: an emerging therapeutic approach for neurological disorders

The functions of the glymphatic system include clearance metabolic waste and modulation water transport in brain, it forms a brain-wide fluid network along with cerebrospinal (CSF) interstitial (ISF). pathway consists periarterial influx CSF, astrocyte-mediated interchange between ISF CSF supported by aquaporin-4 (AQP4) on endfeet astrocyte around periarterioles, perivenous efflux CSF. Finally, is absorbed arachnoid granules or flows into cervical lymphatic vessels. There growing evidence from animal experiments that dysfunction involved many neurological disorders, such as Alzheimer’s disease, stroke, epilepsy, traumatic brain injury meningitis. In this review, we summarize latest progress its driving factors, well changes different diseases. We significantly highlight likely therapeutic approaches for diseases, importance AQP4 normal sleep architecture process.